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41.
Jaime Charris Arthur Barazarte JosÉ Domínguez Gricela Lobo JosÉ Camacho Rosa Ferrer Neira Gamboa Juan Rodrigues Mario V. Capparelli 《Journal of heterocyclic chemistry》2007,44(3):639-643
A series of thieno[ 2 ,3‐b]quinolone derivatives were synthesized and investigated for their abilities to inhibit β‐hematin formation, hemoglobin hydrolysis and in vivo for their efficacy in rodent Plasmodium berghei. Compound 3b was the most promising as inhibitor of hemoglobin hydrolysis, and its effects as inhibitor of β‐hematin formation was promising. When the aromatic ring was substituted in 2 (Me), in 3 (CF3) or in 2,4 (Cl) the inhibition of hemoglobin proteolysis was maximal (88%), the rest of compounds maintained a low inhibition. The most active compound to emerge in vitro and in murine studies, was 3b suggesting an antimalarial activity via multiple mechanisms. 相似文献
42.
General non-commutative supersymmetric quantum mechanics models in two and three dimensions are constructed and some two- and three-dimensional examples are explicitly studied. The structure of the theory studied suggest other possible applications in physical systems with potentials involving spin and non-local interactions. 相似文献
43.
44.
A continuous deformation algorithm is proposed for solving a variational inequality problem on a polytopeK. The algorithm embeds the polytopeK intoK× [0, ) and starts by applying a variable dimension algorithm onK× {0} until an approximate solution is found onK× {0}. Then by tracing the path of solutions of a system of equations the algorithm virtually follows a path of approximate solution inK× [0, ). When the path inK× [0, ) returns to level 0, i.e.,K× {0}, the variable dimension algorithm is again used until a new approximate solution is found onK× {0}. The setK× [0, ) is triangulated so that the approximate solution on the path improves the accuracy as the level increases. A contrivance for a practical implementation of the algorithm is proposed and tested for some test problems.Corresponding author. 相似文献
45.
The properties of the microheterogeneous systems formed by mixtures of cetyltrimethylammonium bromide (CTAB) and an alternating copolymer of maleic acid and styrene, MAS, and their anionic monoesters, MAS-n with n=2, 4, 6, 8, were investigated. The fluorescence of pyrene was used to sense the polarity of the polymer/CTAB aggregates. Measurements of the ratio III/I in pyrene fluorescence spectra indicate that the polymer/CTAB aggregates are more hydrophobic than normal micelles. A series of p-alkyl substituted phenols were employed to probe the solubilization ability of these aggregates. The distribution constant K(S) of phenol, p-methylphenol, p-ethylphenol, and p-propylphenol between water and MAS-n/CTAB aggregates and the corresponding free energy of transfer Deltamicro(0)(t) have been determined using the pseudo-phase model. The results show that the distribution is mainly determined by the phenol structure, and a linear free energy relationship has been found between Deltamicro(0)(t) and the structure of phenols. On the other hand, an increase in the number of methylene groups in the side alkyl chain has no effect on Deltamicro(0)(t). The results are discussed and compared with those obtained for ionic micelles. 相似文献
46.
47.
Juan C. M. Gamboa Roselyn C. Peña Thiago R. L. C. Paixão Alex S. Lima Mauro Bertotti 《Electroanalysis》2010,22(22):2627-2632
The increased surface area of copper electrodes upon applying a suitable potential protocol was characterized by atomic force microscopy images. Scanning electrochemical microscopy was used to demonstrate the enhanced reactivity of the generated surface. The modified electrode showed excellent catalytic activity towards nitrite reduction in acidic medium (pH 2). This new platform was used in the development of a fast and simple voltammetric method for nitrite determination. Commercial and rainwater spiked samples were analyzed and the data showed an excellent agreement with those obtained with a reference spectrophotometric method (Griess reaction) at a confidence level of 95 % (Student’s t‐test). 相似文献
48.
Ricardo E. Gamboa Saraví 《General Relativity and Gravitation》2012,44(7):1769-1786
In order to find out whether empty singular boundaries can arise in higher dimensional Gravity, we study the solution of Einstein’s equations consisting in a (N + 2)-dimensional static and hyperplane symmetric perfect fluid satisfying the equation of state ρ = ηp, being η an arbitrary constant and N ≥ 2. We show that this spacetime has some weird properties. In particular, in the case η > −1, it has an empty (without matter) repulsive singular boundary. We also study the behavior of geodesics and the Cauchy problem for the propagation of massless scalar field in this spacetime. For η > 1, we find that only vertical null geodesics touch the boundary and bounce, and all of them start and finish at z = ∞; whereas non-vertical null as well as all time-like ones are bounded between two planes determined by initial conditions. We obtain that the Cauchy problem for the propagation of a massless scalar field is well-posed and waves are completely reflected at the singularity, if we only demand the waves to have finite energy, although no boundary condition is required. 相似文献
49.
Let M
n
denote the n-th moment space of the set of all probability measures on the interval [0, 1], P
n
the uniform distribution on the set M
n
and r
n + 1 the maximal range of the (n + 1)-th moments corresponding to a random moment point C
n
with distribution P
n
on M
n
. We study several asymptotic properties of the stochastic process (r
⌊nt⌋+1)
t∈[0,T] if n → ∞. In particular weak convergence to a Gaussian process and a large deviation principle are established.
相似文献
50.
For every integer g≥2 we obtain the complete list of groups acting as the full automorphisms groups on hyperelliptic Riemann
surfaces of genus g.
Partially supported by DGICYT PB 89-201 and Science Plan 910021
Partially supported by DGICYT PB 89/379/C02/01 and Science Plan 910021
Partially supported by DGICYT
After the typing of this paper we have heard about a Ph.D. Thesis by Britta Krapp on questions related to the problem studied
here. 相似文献